Table 2.
Univariate and multivariate analyses of prognostic variables in patients with esophageal squamous cell cancer
| Variables | Overall survival | Disease-free survival | ||||||
|---|---|---|---|---|---|---|---|---|
|
| ||||||||
| Univariate analysis | Multivariate analysis | Univariate analysis | Multivariate analysis | |||||
|
| ||||||||
| HR (95% CI) | Pa | HR (95% CI) | Pa | HR (95% CI) | Pa | HR (95% CI) | Pa | |
|
| ||||||||
| Gender (male/female) | 0.901 (0.618–1.314) | 0.589 | 0.901 (0.618–1.314) | 0.589 | ||||
| Age (≤60/>60 years) | 1.466 (1.096–1.961) | 0.010 | 1.445 (1.082–1.932) | 0.013 | ||||
| Location (upper/middle/lower) | 1.192 (0.942–1.510) | 0.144 | 1.195 (0.944–1.513) | 0.139 | ||||
| Length (≤5/>5 cm) | 0.983 (0.736–1.314) | 0.910 | 0.959 (0.719–1.280) | 0.778 | ||||
| Grade (I/II/III) | 1.207 (0.986–1.477) | 0.068 | 1.233 (1.008–1.507) | 0.041 | ||||
| N stage (N1/N2/N3) | 1.326 (1.084–1.621) | 0.006 | 1.385 (1.109–1.730) | 0.004 | 1.451 (1.183–1.780) | 0.000 | 1.539 (1.228–1.927) | 0.000 |
| PT HDAC6 (low/high) | 1.080 (0.809–1.442) | 0.602 | 1.029 (0.771–1.373) | 0.845 | ||||
| MLN HDAC6 (low/high) | 1.526 (1.091–2.135) | 0.014 | 1.456 (1.039–2.039) | 0.029 | 1.439 (1.029–2.011) | 0.015 | 1.432 (1.025–2.002) | 0.033 |
Notes:
a
Cox proportional hazards regression analysis (forward stepwise). Significant differences (P<0.05) are indicated in bold.
Abbreviations: HDAC6, histone deacetylase 6; MLN, metastatic lymph node; PT, primary tumor.