Table 2.

Univariate and multivariate analyses of overall survival in the training cohort

Characteristics	Univariate analysis P	Multivariate analysis
		HR	95% CI	P
Sex	<0.001
Female		Reference
Male		1.183	0.954–1.466	0.126
Age (years)	<0.001
<25		Reference
>51		2.422	1.718–3.414	<0.001
25–51		1.378	1.009–1.883	0.044
Tumor site	<0.001
Axial		Reference
Extremity		0.572	0.442–0.740	<0.001
Histology	<0.001
Conventional osteosarcoma		Reference
Chondroblastic osteosarcoma		0.802	0.605–1.064	0.125
Fibroblastic osteosarcoma		0.803	0.537–1.200	0.285
Telangiectatic osteosarcoma		1.336	0.844–2.117	0.217
Osteosarcoma in Paget disease of bone		2.375	1.121–5.032	0.024
Small cell osteosarcoma		0.337	0.047–2.409	0.278
Central osteosarcoma		0.634	0.281–1.430	0.272
Intraosseous well-differentiated osteosarcoma		<0.001	0.000–7.603E+80	0.933
Parosteal osteosarcoma		1.001	0.487–2.058	0.998
Periosteal osteosarcoma		0.201	0.028–1.441	0.110
High grade surface osteosarcoma		1.040	0.145–7.459	0.969
Tumor stage	<0.001
Localized		Reference
Regional		1.647	1.248–2.174	<0.001
Distant		4.886	3.580–6.666	<0.001
Surgery	<0.001
No		Reference
Yes		0.460	0.339–0.623	<0.001
Size	<0.001
<8.9		Reference
>13.9		2.141	1.617–2.835	<0.001
8.9–13.9		1.391	1.094–1.768	0.008
Grade	<0.001
High		Reference
Low		0.446	0.287–0.694	<0.001
Marital	<0.001
Married		Reference
Unmarried		1.250	0.930–1.681	0.139
Year of diagnosis	0.427
1983–1992		NI
1993–2002
2003–2014
Race	0.917
Black		NI
Other
White