Figure 3.

Stimulated Contraction of Isogenic Pairs of hiPSC-CM EHTs

Auxotonic EHT contractions were recorded at 100 frames per second under stimulated conditions (1 Hz). Stimulated contraction force (A), contraction velocity (B), relaxation velocity (C), and length of contraction (D) are shown. All error bars represent SEM.

Significance was determined by Student’s t test, ^∗p < 0.05 and ^∗∗∗p < 0.001. n = 10 E99K1, 10 E99K1-Corr, 11 NC-Edit-E99K, 11 NC, 5 E99K2, and 7 E99K2-Corr. Red, mutant ACTC E99K; black, wild-type. See also Figure S6.