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editorial
. 2018 Nov 2;9(86):35601–35602. doi: 10.18632/oncotarget.26276

Figure 1. Schematic representation of AgAbs action.

Figure 1

An antibody conjugated to an EBV epitope recognizes its target on a malignant cell. Upon binding, the antibody gets internalized through receptor- mediated endocytosis. The antibody-epitope complex undergoes processing and the viral epitopes binding to MHC II molecules. This is followed by antigen presentation on the cell surface. The viral antigens in complex with the MHC II molecules are then available for recognition by cytotoxic CD4+ T cells.