Table 1. Donor graft and UCB Treg characteristics.
| Patient 1 | Patient 2 | Patient 3 | Patient 4 | Patient 5 | |
|---|---|---|---|---|---|
| Day 0 CD25+ (106) |
25 | 8.3 | 12 | 22 | 15.5 |
| Day 0 CD25+ Purity (%) |
70 | 90 | 96 | 83 | 96 |
| Day 14 TNC (106) |
1492 | 352 | 857 | 1267 | 1242 |
| Day 14 Fold Expansion |
60 | 42 | 71 | 58 | 80 |
| Day 14 % Treg |
86 | 92 | 93 | 88 | 90 |
| Day 14 Pre-Fucosylation CLA (%) |
N/A | N/A | 3.35 | 3.5 | 4.46 |
| Day 14 Post-Fucosylation CLA (%) |
N/A | N/A | 84.8 | 79.6 | 74.7 |
| CB Treg cell dose (1×106 cells/kg) |
1.2 | 1.19 | 1.1 | 1.2 | 1.1 |
| UCB Treg HLA Matching to Recipient | 4 out of 6 | 4 out of 6 | 5 out of 6 | 5 out of 6 | 5 out of 6 |
| Donor Graft HLA Matching to Recipient | CB 1: 4 out of 6 CB 2: 4 out of 6 |
CB 1: 5 out of 6 CB 2: 5 out of 6 |
6 out of 6 | 6 out of 6 | 6 out of 6 |
| Donor total infused cell dose (1×106 cells/kg) | 64.29 (CB#1: 41.27 CB#2: 23.02) |
36.95 (CB#1: 21.88 CB#2: 15.07) |
1486.25 | 635.21 | 2008.61 |
| Donor T cell dose (CD3+) (1×106 cells/kg) |
28.69 (CB#1: 19.04 CB#2: 9.65) |
14.77 (CB#1: 6.74 CB#2: 8.03) |
391.70 | 158.41 | 371.19 |
| Ratio of Donor Tcon: UCB Treg |
24 | 12 | 356 | 132 | 337 |