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TFPI isoform KO sequences flanking the exon deletions or disruption.
| Exon targeted | Flanking sequences |
|---|---|
| α | 5’-TAGGATTCTGCTTTATTCAGAAGAC-(1950 base deletion)-AGCACTTTCCTTG GGTAGGTAACAG-3’ |
| β/γ | 5’-GATATTCGCTG GCCCACTCTTCCTA-(3220 base deletion)-TTGCCCATAGGTTTTGTGTGTGTAT-3’ |
| β | 5’-CCTGAAACTGATATTCGCTGGCCCA-(556 base-deletion plus GCGTTCA)-TGGAGAAAAGTTAATTATTTTCCAA-3’ |
| γ | 5’-CATCTCTTAACAG/CTGCCTTGGTACTGT-3’ (splice site changed to) 5’-CATCTCTTAATATTGCATTGGTACTGT-3’ |
