Table 4.
Associations of knee pain patterns over 1 year with annual percentage cartilage volume loss and incidence of radiographic knee osteoarthritis over 4 years in participants without radiographic knee osteoarthritis at baseline
| Univariable analysis | Multivariable analysisa | |||
|---|---|---|---|---|
| Estimated marginal mean (SE) | p Value | Estimated marginal mean (SE) | p Value | |
| Annual percentage cartilage volume loss in medial compartment | ||||
| No knee pain at both baseline and 1 year | 0.63 (0.03) | 0.63 (0.03)b,c | ||
| Fluctuating knee pain (pain at either time point) | 0.80 (0.08) | 0.01d | 0.81 (0.08)b | 0.01d |
| Persistent knee pain (pain at both time points) | 0.94 (0.12) | 0.93 (0.12)c | ||
| Trend | 0.004 | 0.003 | ||
| Annual percentage cartilage volume loss in lateral compartment | ||||
| No knee pain at both baseline and 1 year | 0.68 (0.03) | 0.68 (0.03)e,f | ||
| Fluctuating knee pain (pain at either time point) | 0.88 (0.08) | 0.008d | 0.89 (0.08)e | 0.005d |
| Persistent knee pain (pain at both time points) | 0.92 (0.11) | 0.93 (0.11)f | ||
| Trend | 0.003 | 0.002 | ||
| OR (95% CI) | p Value | OR (95% CI) | p Value | |
| Incidence of radiographic knee osteoarthritis | ||||
| No knee pain at both baseline and 1 year | 1.00 | 1.00 | ||
| Fluctuating knee pain (pain at either time point) | 1.96 (1.29, 2.99) | 0.002 | 1.62 (1.04, 2.54) | 0.03 |
| Persistent knee pain (pain at both time points) | 2.07 (1.16, 3.72) | 0.01 | 1.57 (0.85, 2.90) | 0.15 |
| Trend | < 0.001 | 0.03 | ||
aAdjusted for age, gender, body mass index and Kellgren-Lawrence grade
bp = 0.04 for between-group difference
cp = 0.02 for between-group difference
dFor difference in annual percentage cartilage volume loss in medial/lateral compartment among the three knee pain pattern groups
ep = 0.01 for between-group difference
fp = 0.03 for between-group difference