Table 5.
Combined allele frequencies and odds ratios in patients with fibromyalgia and healthy controlsa
| Combined alleles | Controls, n (%) | Fibromyalgia, n (%) | Crude OR (95% CI) | p valueb | Age and sex adjusted OR (95% CI) | p valueb |
|---|---|---|---|---|---|---|
| TGACCGCTGC | 193 (26.6) | 340 (45) | 1.0 (reference) | 1.0 (reference) | ||
| TATCCAACCT | 119 (16.4) | 232 (30.7) | 1.107 (0.834–1.469) | 0.483 | 1.106 (0.833–1.47) | 0.487 |
| TGACCACTGC | 160 (22) | 1 (0.1) | 0.004 (0–0.026) | < 0.001 | 0.004 (0.0–0.026) | < 0.001 |
| TAACTACCCT | 66 (9.1) | 146 (19.3) | 1.256 (0.894–1.765) | 0.19 | 1.248 (0.887–1.756) | 0.204 |
| TATCCGACCT | 103 (14.2) | 0 (0) | 0 (0-Inf) | 0.963 | 0 (0-Inf) | 0.963 |
| TAACTGCCCT | 65 (9) | 0 (0) | 0 (0-Inf) | 0.971 | 0 (0-Inf) | 0.97 |
| CAACCACCGC | 20 (2.8) | 37 (4.9) | 1.05 (0.593–1.861) | 0.867 | 1.088 (0.612–1.934) | 0.774 |
Abbreviations: OR odds ratio, CI confidence interval
aMissing data were excluded (n = 51). Among 39 haplotype structures, 7 haplotypes with a frequency of at least 1% in both the patients and controls are presented; the total frequency of the other haplotype structures was 46 (6%) for controls and 30 (3.8%) for patients. Logistic regression models were used to calculate ORs
bComputed for the estimated coefficient of each haplotype in the logistic regression