Table 3.
Basic characteristics of gout cases by ULT exposure with 1 and 3 years after gout diagnosis
| Variable | 1-Year landmark | 3-Year landmark | ||||||
|---|---|---|---|---|---|---|---|---|
| Exposed n = 4198 |
Unexposed n = 35,286 |
Exposed n = 4793 |
Unexposed n = 23,706 |
|||||
| N | % | N | % | N | % | N | % | |
| Mean age (SD) | 58.2 | (12.8) | 56.3 | (13.5) | 56.1 | (12.1) | 55.1 | (12.9) |
| Male | 3485 | 83.0 | 28,809 | 81.6 | 4151 | 86.6 | 19,526 | 82.4 |
| Body mass index | ||||||||
| Normal | 530 | 12.6 | 6385 | 18.1 | 575 | 12.0 | 4335 | 18.3 |
| Underweight | 22 | 0.5 | 292 | 0.8 | 15 | 0.3 | 196 | 0.8 |
| Overweight | 1504 | 35.8 | 13,294 | 37.7 | 1781 | 37.2 | 9036 | 38.1 |
| Obese | 1893 | 45.1 | 12,801 | 36.3 | 2177 | 45.4 | 8581 | 36.2 |
| Missing | 249 | 5.9 | 2514 | 7.1 | 245 | 5.1 | 1558 | 6.6 |
| Smoking status | ||||||||
| Never/ex-smoker | 3808 | 90.7 | 30,501 | 86.4 | 4355 | 90.9 | 20,459 | 86.3 |
| Current smoker | 390 | 9.3 | 4785 | 13.6 | 438 | 9.1 | 3247 | 13.7 |
| Comorbidities | ||||||||
| Diabetes mellitus | 357 | 8.5 | 2114 | 6.0 | 338 | 7.1 | 1259 | 5.3 |
| Treated hypertension | 1539 | 36.7 | 9509 | 26.9 | 1625 | 33.9 | 5856 | 24.7 |
| Rheumatoid arthritis | 40 | 1.0 | 213 | 0.6 | 39 | 0.8 | 122 | 0.5 |
| Heart failure | 200 | 4.8 | 900 | 2.6 | 166 | 3.5 | 372 | 1.6 |
| Myocardial infraction | 219 | 5.2 | 1247 | 3.5 | 216 | 4.5 | 685 | 2.9 |
| Cerebrovascular disease | 176 | 4.2 | 1172 | 3.3 | 143 | 3.0 | 627 | 2.6 |
| Peripheral vascular disease | 118 | 2.8 | 663 | 1.9 | 85 | 1.8 | 351 | 1.5 |
| Anti-diabetic drugs | 233 | 5.6 | 1462 | 4.1 | 208 | 4.3 | 860 | 3.6 |
| NSAIDs | 1082 | 25.8 | 4455 | 12.6 | 1143 | 23.8 | 2887 | 12.2 |
| Previous hospitalisations | 1256 | 29.9 | 8964 | 25.4 | 1200 | 25.0 | 5392 | 22.7 |
| IMD quintiles | ||||||||
| 1 | 871 | 20.7 | 9211 | 26.1 | 1089 | 22.7 | 6338 | 26.7 |
| 2 | 1021 | 24.3 | 8700 | 24.7 | 1178 | 24.6 | 5894 | 24.9 |
| 3 | 889 | 21.2 | 7076 | 20.1 | 977 | 20.4 | 4733 | 20.0 |
| 4 | 764 | 18.2 | 5935 | 16.8 | 827 | 17.3 | 3915 | 16.5 |
| 5 | 647 | 15.4 | 4332 | 12.3 | 717 | 15.0 | 2810 | 11.9 |
| Mean serum urate (SD) μmol/L | 478.4 | (90.8) | 432.2 | (98.1) | 476.5 | (95.7) | 427.3 | (99.1) |
| Mean serum creatinine (SD)* μmol/L | 89.5 | (16.7) | 87.2 | (16.1) | 90.3 | (15.2) | 86.4 | (15.4) |
NSAID non-steroidal anti-inflammatory drug, IMD Index of multiple deprivation
*Missing serum creatinine value = 10,335 (1-year landmark), 5872 (3-year landmark), missing serum urate: 15,638 (1-year landmark), 10,176 (3-year landmark)