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. 2018 Oct 30;20:245. doi: 10.1186/s13075-018-1736-3

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© The Author(s). 2018

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Fig. 5 — Anti-arthritic activity of monoclonal antibodies (mAbs) KH4–8 and KH7–33 in a mouse model of collagen-induced arthritis. a arthritis index, b squeaking score (a value of 0 represents no indication of pain), c paw volume, and (d) body weight, indicating the severity of arthritis in mouse limbs. The number of arthritic limbs was quantitated, and each limb was assigned a severity score of 0–4. Data indicate the number of arthritic limbs per arthritic mouse and the mean severity score of each arthritic limb. The black arrows indicate the starting day (day 15) of mAb or prednisolone administration. NOR (normal), n = 8; CON (negative control), KH4–8, n = 8; KH7–33, n = 8; PRE (prednisolone, positive control), n = 8. Values are expressed as mean ± standard error of the mean. ^###P <0.001 versus the NOR group and *P <0.05, **P <0.01, ***P <0.001 versus the CON group (two-way analysis of variance followed by Bonferroni correction)