Fig. 2.

Histological assessment of ankle joints on day 42 from each group of mice. a Representative sections of the ankle joint stained with hematoxylin and eosin (HE), Safranin O, and tartrate-resistant acid phosphatase (TRAP). b–d Histological scores of inflammation, cartilage damage, and TRAP-positive cell numbers from each group of mice (n = 6 per group). Data represent the mean ± standard error of the mean. Statistical analyses were performed by the Bonferroni-corrected Mann–Whitney U test (*P <0.05). Original magnifications: 40×; scale bar = 500 μm, 100×; scale bar = 250 μm. Abbreviations: C cartilage, Ctrl control, LA laminarin, Pg Porphyromonas gingivalis, T talus