Table 3.
Comparison of baseline demographics and disease characteristics between patients included in this analysis (scorable CSURI at baseline and follow-up) and those excluded (CSURI not scorable at baseline and follow-up)
| Baseline characteristic of study population | Included | Excluded | p value |
|---|---|---|---|
| N | 34 | 27 | |
| Age (years) | 56.6 (47.8–64.8) | 61.7 (53.6–64.6) | 0.25 |
| Male sex | 26 | 30 | 0.79 |
| Smoking habit | |||
| Never smoker | 47 | 37 | 0.23 |
| Ex-smoker | 18 | 37 | |
| Current smoker | 35 | 26 | |
| Bosentan at any time during the observation period | 38 | 33 | 0.69 |
| Disease characteristics | |||
| Time since RP onset (years) | 7.0 (3–15) | 5.0 (2–21) | 0.65 |
| Time since first non-RP manifestation (years) | 4.5 (1–9) | 5.0 (2–12) | 0.44 |
| Cutaneous involvement | |||
| Limited | 59 | 67 | 0.53 |
| Diffuse | 41 | 33 | |
| Erectile dysfunction | 13 | 44 | 0.29 |
| Kidney involvement | 0 | 4 | 0.45 |
| History of renal crisis | 0 | 0 | – |
| RP condition score [20] | 3.8 (2–7) | 5.0 (2–7) | 0.49 |
| mRSS | 8 (6–13) | 9 (4–18) | 0.63 |
| Time since first DU (years) | 1.5 (0.7–4.2) | 2.3 (1.1–5.0) | 0.42 |
| DU | 76 | 74 | 0.83 |
| Number of DUs (in patients with DUs) | 3.0 (1–7) | 3.5 (1–6) | 0.99 |
| Previous major digital vascular complication | |||
| None | 76 | 69 | 0.39 |
| Soft tissue infection | 21 | 15 | |
| Gangrene | 3 | 8 | |
| Autoamputation | 0 | 8 | |
| Laboratory parameters | |||
| ANA positive | 100 | 96 | 0.25 |
| ACA positive | 48 | 45 | 0.83 |
| Scl-70 positive | 34 | 45 | 0.46 |
Data presented as % or median (interquartile range)
ACA anticentromere autoantibodies, ANA anti-nuclear autoantibodies, CSURI capillaroscopic skin ulcer risk index, DU digital ulcer, mRSS modified Rodnan skin score, RP Raynaud’s phenomenon, Scl-70 anti-topoisomerase I autoantibodies