Table 4.

Univariate linear regression of ΔCSURI (defined as the difference of CSURI between baseline and follow-up) and demographics and disease characteristics (n = 34)

Characteristic of study population	Central assessor 1			Central assessor 2
	β	95% CI	p value	β	95% CI	p value
Age (years)	−0.095	−0.75 to 0.56	0.77	0.222	−0.08 to 0.53	0.15
Male sex	−0.92	−19.2 to 17.4	0.92	−3.5	−12.2 to 5.3	0.42
Smoking habit
Never smoker	Reference			Reference
Ex-smoker	3.61	−18.7 to 25.9	0.74	−1.4	− 12.3 to 9.5	0.79
Current smoker	11.54	−6.2 to 29.3	0.20	−3.9	−12.7 to 4.8	0.36
Disease characteristics
Time since RP onset (years)	−0.093	−0.75 to 0.56	0.77	0.096	−0.19 to 0.39	0.50
Time since first non-RP manifestation (years)	−1.16	−2.9 to 0.6	0.18	0.91	0.1 to 1.7	0.025
Time since first DU (years)	−0.81	−3.0 to 1.4	0.46	0.90	0.0 to 1.8	0.046
Previous major digital vascular complication
None	Reference			Reference
Soft tissue infection	−5.62	−25.9 to 14.6	0.58	3.15	−6.4 to 12.7	0.51
Gangrene	5.24	−43.2 to 53.7	0.83	14.74	−8.1 to 37.5	0.20
Cutaneous involvement
Limited	Reference			Reference
Diffuse	4.05	−12.3 to 20.4	0.62	−3.08	−10.9 to 4.8	0.43
Erectile dysfunction	−7.99	−14.2 to −1.8	0.019	−7.28	−21.1 to 6.5	0.25
RP condition score [20] at baseline	−0.51	−2.4 to 1.4	0.59	−0.11	−1.0 to 0.8	0.81
mRSS at baseline	−0.04	−0.9 to 0.9	0.93	− 0.002	−0.4 to 0.4	0.99
Number of DUs at baseline	1.05	−0.8 to 2.9	0.25	0.55	−0.3 to 1.4	0.21
Laboratory parameters
ACA positive	6.08	−10.4 to 22.5	0.46	−0.02	−8.1 to 8.0	0.99
Scl-70 positive	−16.5	−34.8 to 1.8	0.075	−2.73	−12.1 to 6.7	0.56

ACA anticentromere autoantibodies, CI confidence interval, CSURI capillaroscopic skin ulcer risk index, DU digital ulcer, mRSS modified Rodnan skin score, RP Raynaud’s phenomenon, Scl-70 anti-topoisomerase autoantibodies