Data Type	Example #1	Example #2 (Cameron and McClain 1986)
Document and Annotation Identification
Internal ID	CCR005	CCR2000
Annotation Date	Mar 2 2018	Mar 1 2018
Case Report Identification
Title	A case of endocarditis.	Ocular histopathology of acrodermatitis enteropathica.
Authors	Grant AB;Chang CD	Cameron JD;McClain CJ
Year	2017	1986
Journal	World Journal of Medicine and Case Reports	British Journal of Ophthalmology
Institution	Department of Medicine, Division of Cardiology, First General Hospital, Boston, Massachusetts, USA	Department of Ophthalmology, University of Minnesota Medical School, Minneapolis, Minnesota 55455
Corresponding Author	Grant AB	Cameron JD
PMID	25555555	3756122
DOI	10.1011/wjmcr.2017.11.001	NA
Link	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9555555/	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1040795/
Language	English	English
Medical Content
Key Words	brucellosis; endocarditis; mitral valve	NA
Demography	37-year-old male	male child
Geographic Locations	Florida; Rio de Janeiro, Brazil	NA
Life Style	smoker; drinks alcohol occasionally	NA
Family History	third of five children of consanguineous parents; younger brother has chronic eczema	NA
Social History	construction worker	NA
Medical/Surgical History	history of fatigue	8 pound 9 ounce (3884 g) product of an uncomplicated, full term pregnancy; in good health until age 1 month when he developed a blistering skin rash on his cheeks; rash spread to involve the skin around the eyes, nose, and mouth; skin lesions were also noted on the abdomen and extremities; diarrhoea and failure to thrive; skin biopsy at that time showed parakeratosis typical of acrodermatitis enteropathica; treated over the next six years with intermittent courses of broad spectrum antibiotics, breast milk, and diodoquin; partially responded; developed total alopecia, intermittent acrodermatitis, and intermittent diarrhoea with suboptimal weight gain; spasticity attributed to central nervous system involvement by the ae had developed by 8 months of age; several episodes of cardiopulmonary arrest at 11 months; lack of co-ordination of his vocal cords; tracheostomy; by age 18 months the child developed searching nystagmus associated with bilateral optic atrophy and slight attenuation of retinal vessels as well as signs of psychomotor retardation; bilateral keratoconjunctivitis; skin rash; second skin biopsy performed at age 3 again showed parakeratosis typical for ae; severe skin rash and diarrhoea; bilateral gross anterior corneal opacities were seen which had completely resolved by the time he was reexamined at age five; frequent infections including otitis media, urinary tract infections, and skin infections
Disease System	cardiovascular; infectious	digestive; skin; eye; rare
Signs and Symptoms	palpitations and dyspnea in the previous week; presented with lethargy, headache, and chills	severe blepharoconjunctivitis and bilateral anterior corneal vascularisation; severe skin rash and diarrhoea; gram-negative bacterial sepsis; skin lesions typical of acrodermatitis enteropathica, absence of thymic tissue, marked degeneration of the optic nerves, chiasm, and optic tracts and extensive cerebellar degeneration
Comorbidity	hypertension; hyperlipidemia	NA
Diagnostic Techniques and Procedures	Physical examination; electrocardiography; blood cultures	ocular examination; necropsy
Diagnosis	Brucella endocarditis	acrodermatitis enteropathica
Laboratory Values	increase in c-reactive protein (9 mg/dl); alkaline phosphatase (250 u/l)	NA
Pathology	Brucella melitensis was cultured from blood samples	right and left eyes were similar in appearance; corneal epithelium was reduced in thickness to one to three cell layers of flattened squamous epithelial cells over the entire surface of the cornea; all polarity of the epithelium was lost. bowman's membrane could be identified only in the periphery of the right cornea. no bowman's membrane could be identified in the left cornea. neither degenerative nor inflammatory pannus could be identified in either eye; extensive atrophy of the circular and oblique muscles of the ciliary body; some posterior migration of lens capsular epithelium and early cortical degenerative changes; extensive degeneration of the retinal pigment epithelium throughout the posterior pole; retina was attached and showed mild autolytic changes throughout; some preservation of rod and cone outer segments in the posterior pole, however, these structures were completely lost anterior to the equator; extensive loss of the ganglion cell and nerve fibre layers of both eyes; nearly complete atrophy of the disc and adjacent optic nerve
Pharmacological Therapy	gentamycin 240 mg/iv/daily	NA
Inverventional Therapy	prosthetic valve replacement	NA
Patient Outcome Assessment	recovery was uneventful; discharged home	died in 1971 (age 7)
Diagnostic Imaging/Videotape Recording	2;1;0;1	7;0;0;0
Relationship to Other Case Reports	5555555	23430849
Relationship with Clinial Trial	NCT05555123	NA
Crosslink with Database	MedlinePlus Health Information: https://medlineplus.gov/ency/article/000597.htm	HighWire - PDF: http://bjo.bmj.com/cgi/pmidlookup?view=long&pmid=3756122; Europe PubMed Central: http://europepmc.org/abstract/MED/3756122; Genetic Alliance: http://www.diseaseinfosearch.org/result/143
Acknowledgements
Funding Source	National Institutes of Health/National Heart, Lung, and Blood Institute	The Minnesota Lions Club; Research to Prevent Blindness; Veterans Administration; Office of Alcohol and Other Drug Abuse Programming of the State of Minnesota
Award Number	R01HL123123 (to AG)	NA
Disclosures/Conflict of Interest	Dr. Grant is a paid spokesperson for DrugCo.	NA
References	4	27