Table 4. Kinetic deuterium isotope effect on intrinsic clearance for deuterated forms of 1a with human liver microsomes and recombinant CYP3A4.
| HCLint / DCLint | ||
|---|---|---|
| Compound | HLM | CYP3A4 |
| (1b) | 1.0 | 1.0 |
| (1c) | 1.0 | 1.1 |
| (1d) | 1.0 | 1.2 |
| (1e) | 1.0 | 1.0 |
| (1f) | 1.1 | 1.2 |
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