Table 6. Kinetic deuterium isotope effect on intrinsic clearance for deuterated forms of 2a with human liver microsomes, r-CYP3A4 and r-CYP2C19.
| HK / DK | |||
|---|---|---|---|
| Compound | HLM | CYP3A4 | CYP2C19 |
| (2b) | 1.3 | 1.2 | 4.0 |
| (2c) | 1.5 | 2.9 | 1.0 |
| (2d) | 3 | 8.3 | 4.5 |
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