Skip to main content
. 2018 Nov 9;11:7919–7934. doi: 10.2147/OTT.S180971

Figure 2.

Figure 2

Effect of miR-18a on the proliferation of HCC cells.

Notes: (A) miR-18a mimic increased miR-18a level (P<0.01 in the HepG2 cell and P<0.001 in the SMMC7721 cell) and miR-18a inhibitor decreased miR-18a level (P<0.05) in HCC cell lines. (B) Upregulation of miR-18a in HCC cells facilitated cell proliferation while downregulation of miR-18a inhibited cell proliferation. (C) Cell apoptosis rate was detected by flow cytometry after transfection with miR-18a inhibitor or miR-18a mimic. (D) The proportion of cells in each cell cycle phase was detected using flow cytometry after the cells were transfected with miR-18a inhibitor or miR-18a mimic. Data were reported as mean ± SD. *P<0.05, **P<0.01, and ***P<0.001.

Abbreviations: HCC, hepatocellular carcinoma; miR-18a, microRNA-18a; NC, negative control; PI, propidium iodide.