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. 2018 Nov 9;11:7919–7934. doi: 10.2147/OTT.S180971

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© 2018 Wang et al. This work is published and licensed by Dove Medical Press Limited

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Effect of miR-18a on migration and invasion of HCC cells in vitro.

Notes: (A) The effect of miR-18a on cell migration was determined by a wound scratching assay. Cell migration capacity of miR-18a mimic transfected HCC cells was promoted (P<0.05), whereas cell migration capacity of miR-18a inhibitor transfected HCC cells was inhibited (P<0.05). Scale bars =200 µm; magnification 40×. (B) After transfection of cells with miR-18a, the ability of cells to pass through the basement membrane was enhanced (P<0.001). In contrast, after transfecting cells with miR-18a inhibitor, the ability was inhibited (P<0.001). Scale bars =20 µm; magnification 100×. Data were reported as mean ± SD. ***P<0.001.

Abbreviations: HCC, hepatocellular carcinoma; miR-18a, microRNA-18a; NC, negative control.