Skip to main content
. Author manuscript; available in PMC: 2019 Apr 30.
Published in final edited form as: Nat Methods. 2018 Oct 30;15(11):962–968. doi: 10.1038/s41592-018-0176-y

Figure 1: HUMAnN2 functionally profiles microbial communities with high accuracy using tiered search.

Figure 1:

(a) Overview of HUMAnN2’s tiered search algorithm for meta’omic functional profiling (expanded in Supplementary Fig. 1). (b) HUMAnN2’s tiered search vs. pure translated search evaluated on a synthetic gut metagenome. Sensitivity, precision, and overall accuracy (1 - Bray-Curtis dissimilarity) were computed for (c) gene family and (d) pathway abundance profiles relative to gold standards at the whole-community level (“overall”) and for each stratification. (e) HUMAnN2 compared with other methods in the task of quantifying community-total COG abundances. Runtimes reflect multi-threaded execution on 8 CPU cores.