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. 2018 Nov 14;4(11):eaav0824. doi: 10.1126/sciadv.aav0824

Fig. 1. Two components of M. oppositifolius leaf extract activate KCNQ1 channels.

Fig. 1

(A) M. oppositifolius (Geiseler) Mull. Arg. Photo by E. Bidault. Source: Tropicos.org. Missouri Botanical Garden (http://tropicos.org/Image/100521734). (B) KCNQ1 topology (two of four subunits shown). (C) Structure and electrostatic surface potential (blue, positive; green, neutral; red, negative) of M. oppositifolius leaf extract components. (D) Averaged KCNQ1 current traces in response to voltage protocol (upper inset) when bathed in the absence (control) or presence of M. oppositifolius leaf extract components (n = 5 to 8). Dashed line indicates zero current level in these and all following current traces. (E) Mean effects of leaf extract components [as in (D); n = 5 to 8] on KCNQ1 raw tail currents at −30 mV after prepulses as indicated (left); G/Gmax calculated from tail currents (right). Error bars indicate SEM. Ctrl, control.