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. 2018 Nov 14;4(11):eaav0824. doi: 10.1126/sciadv.aav0824

Fig. 2. MTX and CPT1 each activate KCNQ1 channels.

Fig. 2

All error bars indicate SEM. (A) Voltage dependence of KCNQ1 current fold increase by MTX (30 μM), plotted from traces as in Fig. 1 (n = 7). (B) Dose response of KCNQ1 channels at −40 mV for MTX (calculated EC50 = 10 μM; n = 7). (C) Dose response for mean ΔV0.5 of activation induced by MTX for KCNQ1 (n = 7). (D) Voltage dependence of KCNQ1 current fold increase by CPT1 (100 μM), plotted from traces as in Fig. 1 (n = 4 to 6). (E) Dose response of KCNQ1 channels at −60 mV for CPT1 (n = 4 to 6). (F) Dose response for mean ΔV0.5 of activation induced by CPT1 for KCNQ1 (n = 4 to 6).