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. 2018 Oct 25;7:e38588. doi: 10.7554/eLife.38588

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© 2018, Dorman et al

This article is distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use and redistribution provided that the original author and source are credited.

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Figure 5. — (A) Spine calcium traces (top) are shown for a single proximal spine, either when synaptically stimulated alone (dark dashed line); unstimulated during synaptic stimulation of clustered distal spines (light dashed line); or stimulated simultaneously with clustered distal stimulation (solid yellow line). Proximal spine calcium elevation is higher when stimulated with clustered distal stimulation than the sum of the proximal spine calcium responses to only distal cluster stimulation and only proximal spine stimulation. Corresponding membrane potential at the dendritic shaft is shown below. (B) Temporal dependence governing the interaction between proximal synaptic stimulation (same y axis as (A)) and synaptic stimulation of a distal cluster of spines. Traces are temporally aligned to the onset of stimulation of the proximal spine synapse, while paired with distal clustered spine stimulation at varying temporal intervals. When the distal cluster stimulation precedes the single proximal synaptic input by 25 ms (black trace), elevated calcium is produced in the proximal spine, but not for a longer delay (50 ms) or when the single proximal stimulus precedes the distal clustered stimulation. Dendritic membrane potential traces (bottom) show the temporal dependence of peak calcium facilitation on depolarization in the proximal dendritic shaft; in each trace, the proximal stimulus occurs at 0.1 ms on the x axis.