Table 2.
Adjusted longitudinal association of rest-activity rhythms and development of clinically significant cognitive decline (assessed by 3MS score1) in older men (n=2754)
| Outcome/ Predictor |
Category | N of events (%) | Age + Clinic Adjusted Odds Ratio (95% CI) |
Multivariable Adjusted* Odds Ratio (95% CI) |
|---|---|---|---|---|
| Amplitude (counts/min) | Q1: <2962.5 | 154 (26.9) | 1.5 (1.1, 2.0) | 1.4 (1.0, 1.9) |
| Q2: 2962.5 to <3568.9 | 93 (15.1) | 0.8 (0.6, 1.1) | 0.8 (0.6, 1.1) | |
| Q3: 3568.9 to <4218.8 | 108 (17.1) | 1.0 (0.7, 1.3) | 1.0 (0.7, 1.4) | |
| Q4: ≥4218.8 | 103 (16.5) | Ref | Ref | |
| p-trend | 0.03 | 0.12 | ||
| Mesor (counts/min) | Q1: <1868.4 | 137 (23.1) | 1.13 (0.9, 1.5) | 1.1 (0.8, 1.4) |
| Q2: 1868.4 to <2143.8 | 105 (17.2) | 0.8 (0.6, 1.1) | 0.9 (0.6, 1.2) | |
| Q3: 2143.8 to <2431.7 | 102 (16.4) | 0.8 (0.6, 1.1) | 0.8 (0.6, 1.1) | |
| Q4: ≥2431.7 | 114 (18.4) | Ref | Ref | |
| p-trend | 0.37 | 0.63 | ||
| Pseudo F-statistic | Q1: <705.9 | 151 (25.7) | 1.5 (1.2, 2.1) | 1.4 (1.0, 1.9) |
| Q2: 705.9 to <978.9 | 100 (16.6) | 0.9 (0.7, 1.3) | 0.9 (0.7, 1.3) | |
| Q3: 978.9 to <1320.6 | 105 (16.8) | 1.0 (0.7, 1.3) | 1.0 (0.7, 1.3) | |
| Q4: ≥1320.6 | 102 (16.1) | Ref | Ref | |
| p-trend | <0.01 | 0.04 | ||
| Acrophase2 (time) | <12:28PM | 39 (30.7) | 1.9 (1.3, 2.8) | 1.8 (1.2, 2.8) |
| 12:28PM to 4:06PM | 392 (17.9) | Ref | Ref | |
| >4:06PM | 27 (20.8) | 1.2 (0.7, 1.8) | 1.03 (0.6, 1.6) |
1
Decline on 3MS of 5 points
2
<12:28 PM (phase advanced), >4:06 PM (phase delayed)
*
Multivariate models are adjusted by age, clinic site, race (white vs. nonwhite), body mass index, education, depression, history of comorbid conditions, benzodiazepine use, anti-depressant use, self-reported health status, IADL impairment, alcohol use, caffeine use and smoking. P-trends are from a test of linear trend across quartiles. All other p-values are pairwise comparisons of each quartile to the reference.