BI=Barthel index; CI=confidence interval; SBI=subclinical brain infarct; MI=myocardial infarction; pSBI=pathology-informed subclinical brain infarct; RF=risk factor; QOL=quality of life; Adj=adjusted for Demographics and vascular risk factor model is adjusted for age at time of MRI, sex, race, diabetes, hypertension, coronary artery disease, hypercholesterolemia, physical activity, alcohol use, smoking, and body mass index at the time of MRI QOL and depression model is additionally adjusted for: marital status, insurance, number of friends, years lived in the community, mini-mental state score, and Spitzer quality of life index and depression Stroke and MI model is additionally adjusted for stroke and MI occurring during follow-up, as time-varying covariates