Table 2.
Association of subclinical brain infarcts by location with change in functional status *
| Variable | Estimate | 95% CI | p-value |
|---|---|---|---|
| Model 1: SBI, superficial/cortical location:* | |||
| Annual change in BI | −0.92 | −1.08, −0.76 | <.0001 |
| Difference in BI with cortical SBI location** | 0.27 | −3.29, 3.83 | 0.9 |
| Additional annual change with cortical SBI location** | −0.79 | −1.63, 0.06 | 0.068 |
| Model 2: SBI, subcortical location:* | |||
| Annual change in BI | −0.88 | −1.04, −0.72 | <.0001 |
| Difference in BI with subcortical SBI location** | 1.21 | −1.87, 4.29 | 0.4 |
| Additional annual change with subcortical SBI location** | −1.11 | −1.81, −0.41 | 0.002 |
| Model 3: SBI, testing location:* | |||
| Annual change in BI | −0.85 | −1.01, −0.69 | <.0001 |
| Difference in BI with cortical SBI location† | 0.70 | −2.93, 4.34 | 0.7 |
| Difference in BI with subcortical SBI location† | 1.81 | −1.14, 4.76 | 0.2 |
| Difference in BI with both cortical and subcortical SBI location† | 0.73 | −9.15, 10.62 | 0.9 |
| Additional annual change with cortical SBI location† | −0.49 | −1.36, 0.38 | 0.3 |
| Additional annual change with subcortical SBI location† | −0.90 | −1.60, −0.20 | 0.01 |
| Additional annual change with both cortical and subcortical SBI location† | −2.68 | −5.03, −0.32 | 0.03 |
| Model 4: pSBI, testing location:* | |||
| Annual change in BI | −0.82 | −0.98, −0.66 | <.0001 |
| Difference in BI with cortical pSBI location† | 2.33 | −0.31, 4.98 | 0.084 |
| Difference in BI with subcortical pSBI location† | 3.54 | −0.45, 7.53 | 0.082 |
| Difference in BI with both cortical and subcortical pSBI location† | −0.74 | −6.84, 5.36 | 0.8 |
| Additional annual change with cortical pSBI location† | −0.95 | −1.72, −0.17 | 0.017 |
| Additional annual change with subcortical pSBI location† | −1.35 | −2.37, −0.33 | 0.009 |
| Additional annual change with both cortical and subcortical pSBI location† | −1.23 | −2.63, 0.17 | 0.086 |
SBI=subclinical infarct; pSBI=pathology-informed SBI; BI=Barthel index; CI=confidence interval; MI=myocardial infarction
*
models are additionally adjusted for: age at the time of MRI, sex, race-ethnicity, diabetes, hypertension, coronary artery disease, hypercholesterolemia, physical activity, alcohol use, smoking, body mass index, marital status, insurance status, number of friends, mini-mental state score, and stroke and myocardial infarction occurring during follow-up
†
versus no SBI
**
versus no SBI in this location