Table 3.

[¹¹C]IMA107 SRTM binding potential relative to nondisplaceable uptake (BP_ND, unitless)

	BPND before correction for partial volume effects		BPND after correction for partial volume effects
	Cocaine use disorder	Healthy controls	Cocaine use disorder	Healthy controls
Ventral Striatum	0.94 ± 0.15	0.93 ± 0.21	1.66 ± 0.22	1.67 ± 0.42
Caudate	1.09 ± 0.28	1.26 ± 0.22	1.59 ± 0.29	1.72 ± 0.31
Putamen	2.22 ± 0.25	2.33 ± 0.26	2.44 ± 0.26	2.57 ± 0.34
Midbrain	0.42 ± 0.08	0.42 ± 0.07	0.50 ± 0.13	0.49 ± 0.16
Thalamus	0.31 ± 0.06	0.34 ± 0.05	0.33 ± 0.06	0.36 ± 0.07
Globus Pallidus	2.23 ± 0.29	2.43 ± 0.23	2.47 ± 0.38	2.71 ± 0.38

Values are mean ± SD in cocaine use disorder and healthy control subjects (n = 15/group);

No significant increase in individual regional BP_ND are noted in cocaine use disorder compared to healthy controls (Bonferroni-corrected p > 0.008 for all between-group contrasts, one-tailed unpaired t-tests)