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. 2018 Sep 24;143(11):2709–2717. doi: 10.1002/ijc.31655

Table 2.

Rotating night shift work duration and colorectal cancer risk in the Nurses’ Health Study, 1988–2012 (N = 77,439)

No. of cases Person‐yrs RR (95% CI)1 p‐trend1 , 3 RR (95% CI)2 p‐trend2 , 3
NHS baseline rotating night shift work history in years
Never 584 634,953 1.0 (ref) 1.0 (ref)
1–2 346 376,925 1.02 (0.90, 1.17) 1.04 (0.91, 1.19)
3–4 269 257,258 1.05 (0.91, 1.22) 1.05 (0.91, 1.22)
5–9 112 104,179 1.08 (0.88, 1.32) 1.06 (0.87, 1.30)
10–14 73 69,547 1.04 (0.82, 1.33) 1.01 (0.79, 1.29)
15–19 45 42,259 1.05 (0.78, 1.43) 1.02 (0.75, 1.39)
20–29 59 41,964 1.34 (1.02, 1.76) 1.26 (0.96, 1.65)
30+ 39 24,740 1.21 (0.87, 1.68) 0.04 1.17 (0.84, 1.63) 0.14
1,527 1,551,827
NHS baseline rotating night shift work history in years 4
Never 584 634,953 1.0 (ref) 1.0 (ref)
1–14 800 807,909 1.04 (0.94, 1.16) 1.04 (0.94, 1.16)
15+ 143 108,964 1.20 (1.00, 1.45) 1.15 (0.95, 1.39)
1,527 1,551,827
1

Adjusted for age (months) and follow‐up cycle.

2

Adjusted for age (months), height (continuous in inches), BMI (<18.5, 18.5–24.9, 25.0–29.9, ≥30 kg/m2), educational level (RN license, bachelor's degree, masters or doctoral degree), menopausal status (premenopausal, postmenopausal), menopausal hormone therapy (never, past, current), first‐degree family history of colorectal cancer (yes, no), alcohol consumption (0, 0.1–4.9, 5–14.9, ≥15 g/day), physical activity (≤8, 8.1–16, 16.1–24, >24 MET‐hr/week), smoking status (never smoker, current smoker, past smoker), colonoscopy/sigmoidoscopy in the previous 2 years (yes, no), current regular aspirin or NSAIDS use (>2 tablets/week), daily energy intake (kcal/day), red or processed meat (servings/day) and folate consumption (ug/day) in quintiles.

3

p‐trend was calculated using the midpoint of each category of rotating shift work duration in years (1–2, 3–4, 5–9, 10–14, 15–19, 20–29, 30+).

4

Categories of shift work duration (Never, 1–14 years, 15+ years) were used to compare with our previously published results.