Table 2.
No. of cases | Person‐yrs | RR (95% CI)1 | p‐trend1 , 3 | RR (95% CI)2 | p‐trend2 , 3 | |
---|---|---|---|---|---|---|
NHS baseline rotating night shift work history in years | ||||||
Never | 584 | 634,953 | 1.0 (ref) | 1.0 (ref) | ||
1–2 | 346 | 376,925 | 1.02 (0.90, 1.17) | 1.04 (0.91, 1.19) | ||
3–4 | 269 | 257,258 | 1.05 (0.91, 1.22) | 1.05 (0.91, 1.22) | ||
5–9 | 112 | 104,179 | 1.08 (0.88, 1.32) | 1.06 (0.87, 1.30) | ||
10–14 | 73 | 69,547 | 1.04 (0.82, 1.33) | 1.01 (0.79, 1.29) | ||
15–19 | 45 | 42,259 | 1.05 (0.78, 1.43) | 1.02 (0.75, 1.39) | ||
20–29 | 59 | 41,964 | 1.34 (1.02, 1.76) | 1.26 (0.96, 1.65) | ||
30+ | 39 | 24,740 | 1.21 (0.87, 1.68) | 0.04 | 1.17 (0.84, 1.63) | 0.14 |
1,527 | 1,551,827 | |||||
NHS baseline rotating night shift work history in years 4 | ||||||
Never | 584 | 634,953 | 1.0 (ref) | 1.0 (ref) | ||
1–14 | 800 | 807,909 | 1.04 (0.94, 1.16) | 1.04 (0.94, 1.16) | ||
15+ | 143 | 108,964 | 1.20 (1.00, 1.45) | 1.15 (0.95, 1.39) | ||
1,527 | 1,551,827 |
Adjusted for age (months) and follow‐up cycle.
Adjusted for age (months), height (continuous in inches), BMI (<18.5, 18.5–24.9, 25.0–29.9, ≥30 kg/m2), educational level (RN license, bachelor's degree, masters or doctoral degree), menopausal status (premenopausal, postmenopausal), menopausal hormone therapy (never, past, current), first‐degree family history of colorectal cancer (yes, no), alcohol consumption (0, 0.1–4.9, 5–14.9, ≥15 g/day), physical activity (≤8, 8.1–16, 16.1–24, >24 MET‐hr/week), smoking status (never smoker, current smoker, past smoker), colonoscopy/sigmoidoscopy in the previous 2 years (yes, no), current regular aspirin or NSAIDS use (>2 tablets/week), daily energy intake (kcal/day), red or processed meat (servings/day) and folate consumption (ug/day) in quintiles.
p‐trend was calculated using the midpoint of each category of rotating shift work duration in years (1–2, 3–4, 5–9, 10–14, 15–19, 20–29, 30+).
Categories of shift work duration (Never, 1–14 years, 15+ years) were used to compare with our previously published results.