Table 2. Association between unlagged cumulative arsenic and bladder cancer risk stratified by demographic and lifestyle factors.
| Cumulative Arsenic (mg) | ||||||||
|---|---|---|---|---|---|---|---|---|
| 0–15.70 | >15.70–34.50 | >34.50–77.04 | >77.04 | |||||
| Ca/Co | OR* (95% CI) | Ca/Co | OR* (95% CI) | Ca/Co | OR* (95% CI) | Ca/Co | OR* (95% CI) | |
| Age | ||||||||
| <55 | 48/73 | 1.0 (ref) | 48/55 | 1.3 (0.7, 2.3) | 33/58 | 0.8 (0.4, 1.5) | 37/48 | 1.1 (0.6, 2.1) |
| 55–64 | 57/85 | 1.0 (ref) | 78/78 | 1.5 (0.91, 2.5) | 80/66 | 1.7 (0.99, 2.8) | 76/74 | 1.6 (0.95, 2.8) |
| 65–74 | 82/112 | 1.0 (ref) | 106/115 | 1.1 (0.7, 1.7) | 93/134 | 0.9 (0.6, 1.4) | 119/132 | 1.1 (0.7, 1.7) |
| 75+ | 41/57 | 1.0 (ref) | 56/73 | 1.0 (0.6, 1.8) | 57/63 | 1.3 (0.7, 2.3) | 68/64 | 1.7 (0.96, 3.0) |
| p-interaction=0.53 | ||||||||
| Sex | ||||||||
| Female | 54/84 | 1.0 (ref) | 71/83 | 1.2 (0.7, 1.9) | 71/91 | 1.1 (0.6, 1.8) | 62/83 | 1.2 (0.7, 2.0) |
| Male | 174/243 | 1.0 (ref) | 217/238 | 1.2 (0.88, 1.6) | 192/230 | 1.2 (0.85, 1.5) | 238/235 | 1.4 (1.02, 1.9) |
| p-interaction=0.95 | ||||||||
| Smoking | ||||||||
| Never smokers | 50/122 | 1.0 (ref) | 41/90 | 1.2 (0.7, 2.1) | 36/113 | 0.9 (0.5, 1.5) | 37/105 | 1.1 (0.6, 1.9) |
| Former smokers | 108/146 | 1.0 (ref) | 151/178 | 1.1 (0.8, 1.6) | 139/152 | 1.3 (0.89, 1.8) | 152/162 | 1.4 (0.96, 2.0) |
| Current smokers | 64/47 | 1.0 (ref) | 89/46 | 1.5 (0.8, 2.6) | 86/46 | 1.3 (0.7, 2.3) | 104/42 | 1.6 (0.91, 3.0) |
| p-interaction=0.49 | ||||||||
| Usual BMI (kg/m2) | ||||||||
| Normal Weight | 97/142 | 1.0 (ref) | 105/133 | 0.9 (0.6, 1.4) | 111/136 | 1.1 (0.7, 1.6) | 124/119 | 1.3 (0.89, 2.0) |
| Overweight | 91/140 | 1.0 (ref) | 123/136 | 1.5 (0.99, 2.2) | 93/147 | 1.1 (0.7, 1.7) | 117/134 | 1.6 (1.1, 2.4) |
| Obese | 33/33 | 1.0 (ref) | 55/45 | 1.2 (0.6, 2.3) | 49/36 | 1.2 (0.6, 2.4) | 55/62 | 0.9 (0.4, 1.8) |
| p-interaction=0.14 | ||||||||
| Folate (mcg/day) | ||||||||
| >400 | 97/159 | 1.0 (ref) | 127/146 | 1.4 (0.97, 2.1) | 111/160 | 1.2 (0.8, 1.8) | 131/141 | 1.6 (1.1, 2.4) |
| 0–400 | 104/132 | 1.0 (ref) | 135/143 | 1.1 (0.7, 1.5) | 126/128 | 1.1 (0.8, 1.7) | 126/142 | 1.1 (0.7, 1.7) |
| p-interaction=0.55 | ||||||||
| Any Alcohol | ||||||||
| Ever | 160/235 | 1.0 (ref) | 212/222 | 1.3 (0.98, 1.8) | 173/223 | 1.1 (0.8, 1.5) | 177/205 | 1.3 (0.92, 1.7) |
| Never | 46/56 | 1.0 (ref) | 54/72 | 0.7 (0.4, 1.3) | 66/66 | 1.2 (0.7, 2.1) | 83/82 | 1.4 (0.8, 2.4) |
| p-interaction=0.23 | ||||||||
*ORs are adjusted for age, sex, ethnicity, state of residence, smoking (including duration for smoking strata), disinfection by products, and high-risk occupation. ¶ p-interaction for ever/never smokers = 0.24.