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. Author manuscript; available in PMC: 2019 Jan 1.
Published in final edited form as: Eur J Pharm Sci. 2018 Jun 19;126:33–48. doi: 10.1016/j.ejps.2018.06.011

Table 2.

Study design for the rat multi-dose study.

Group E Group F
Saline (4×) Particles + prednisolone + magnet
Ears to be treated In one ear In one ear
Number of animals N =4 N = 4
Day of treatment Measure hearing by ABR at rat hearing frequencies (8, 12, 16, 24, 32 kHz)
1st treatment Intra-tympanic saline Intra-tympanic particles with prednisolone, then apply magnet
1 week after After Measure hearing by ABR at rat hearing frequencies (8, 12, 16, 24, 32 kHz)
2nd treatment Intra-tympanic saline Intra-tympanic particles with prednisolone, then apply magnet
1 week after After Measure hearing by ABR at rat hearing frequencies (8, 12, 16, 24, 32 kHz)
3rd treatment Intra-tympanic saline Intra-tympanic particles with prednisolone, then apply magnet
1 week after after Measure hearing by ABR at rat hearing frequencies (8, 12, 16, 24, 32 kHz)
4th treatment Intra-tympanic saline Intra-tympanic particles with prednisolone, then apply magnet
1 month after Measure hearing by ABR at rat hearing frequencies (8, 12, 16, 24, 32 kHz)
treatment Terminate all (N = 8) animals per group. Measure iron, drug in ear, major organs. Ear histology.