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Distance distribution of catalytic active site loops in ASD- vs. cancer-associated mutations. The distance distribution between backbone Cα atoms of catalytic residues D92 and R130 illustrates occurrence of loss of interaction and/or steric hindrance between the two functionally crucial residues in (a) ASD (only), (b) cancer (only), (c) mutations shared across both phenotypes, and (d) one mutation with coexisting phenotypes in comparison to WT PTEN.
