Table 2.
Comparison between average geometric properties of ASD- vs. cancer-associated mutations
| Phenotype | Genotype | RMSD (nm) average | Rg (nm) maximum |
|---|---|---|---|
| WT PTEN | - | 0.257 | 2.23 |
| ASD (only) | p.L23F | 0.292 | 2.23 |
| p.Y65C | 0.247 | 2.23 | |
| p.Y68H | 0.219 | 2.18 | |
| p.I101T | 0.266 | 2.24 | |
| p.I122S | 0.278 | 2.31 | |
| p.L220V | 0.277 | 2.21 | |
| Cancer (only) | p.D24G | 0.270 | 2.30 |
| p.D92A | 0.324 | 2.29 | |
| p.R130G | 0.255 | 2.26 | |
| p.M134R | 0.303 | 2.28 | |
| p.M205V | 0.237 | 2.22 | |
| p.L345V | 0.300 | 2.22 | |
| ASD or Cancer (shared) | p.R130Q | 0.291 | 2.20 |
| p.C136R | 0.255 | 2.24 | |
| p.Y155C | 0.256 | 2.26 | |
| p.R173C | 0.302 | 2.31 | |
| ASD and Cancer (coexisting) | p.S170I | 0.266 | 2.26 |