Table 1.
Summary of trafficking protein function during morphogenesis and planar polarity.
| Protein | Organism | Subcellular structure |
Polarity | Process | Function |
|---|---|---|---|---|---|
|
| |||||
| Rab4 | Zebrafish | Endosome | Epiboly cell migration | E-cad recycling58 | |
|
| |||||
| Rab5 | Drosophila embryo | Early endosome | Apical cytoplasm | Epithelial formation | Microvilli uptake54 |
| Germband extension | Associates with Rab3534 | ||||
|
|
|
||||
| Drosophila wing | Wing development | Fmi redistribution80 | |||
|
|
|
||||
| Zebrafish | Epiboly cell migration | E-cad recycling58 | |||
|
|
|
||||
| Xenopus | Apical | Bottle cell formation | Apical constriction52 | ||
|
| |||||
| Rab11 | Drosophila embryo | Recycling endosome | Apical cytoplasm | Epithelium formation | Membrane trafficking53 |
|
|
|
||||
| Drosophila wing | Apical cytoplasm | Wing development | PCP trafficking84 | ||
| Cell packing61 | |||||
|
|
|
||||
| Xenopus | Neural tube folding | Apical constriction56 | |||
| Myosin II activation55 | |||||
| PCP trafficking55,56 | |||||
|
|
|
||||
| Zebrafish | Epiboly cell migration | E-cad recycling58 | |||
|
| |||||
| Rab35 | Drosophila embryo | Endocytic compartments | AP interface | Germband extension | Interface contraction34 |
|
| |||||
| AP2 | Drosophila embryo | Endocytosis | AP interface | Germband extension | E-cad uptake33 |
|
| |||||
| Clathrin | Drosophila embryo | Endocytosis | AP interface | Germband extension | E-cad uptake33 |
| Rab35 compartment termination34 | |||||
|
| |||||
| Dynamin | Drosophila embryo | Endocytosis | Apical | Epithelium formation | Microvilli uptake53,54 |
|
| |||||
| AP interface | Germband extension | E-cad uptake33 | |||
| Rab35 compartment termination34 | |||||
|
| |||||
| Arf1 | Drosophila wing | Transport vesicles | Proximal to distal | Wing development | PCP trafficking73 |
|
| |||||
| Sec5/Sec15/exocyst | Drosophila embryo | Exocyst complex, plasma membrane | Apical | Epithelium formation | Exocytic trafficking38,39 |
|
|
|||||
| Drosophila wing | Wing development | Exocytic trafficking61 | |||
| Cell packing61 | |||||
|
|
|||||
| Xenopus | Apical surface | Neural tube folding | Apical constriction55 | ||