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Overview of Melanin synthesis compared to neuronal dopamine synthesis. Both L-DOPA and dopamine are derived from tyrosine, with an intermediate production of L-DOPA. In neurons, L-DOPA is decarboxylated to form dopamine. In RPE, L-DOPA is further reacted with tyrosinase to create an indole, which is then polymerized to form insoluble melanin
