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. Author manuscript; available in PMC: 2019 Jul 1.
Published in final edited form as: J Neurosci Res. 2018 May 14;97(1):77–87. doi: 10.1002/jnr.24246

Figure 2.

Figure 2

RPE express the full complement of melanogenic proteins, including GPR143. This figure illustrates the autocrine loop created in the melanogenic system when the cells synthesize melanin, they release LDOPA as a byproduct, L-DOPA then activates GPR143, stimulating the secretion of PEDF.