Official websites use .gov
A
.gov website belongs to an official
government organization in the United States.
Secure .gov websites use HTTPS
A lock (
) or https:// means you've safely
connected to the .gov website. Share sensitive
information only on official, secure websites.
Activation of GPR143 controls several RPE activities that could contribute to retinal health and disease. L-DOPA activation of GPR143 upregulates RPE secretion of PEDF while simultaneously down regulating VEGF. GPR143 signaling halts apical exosome release, and could alter basal exosome release, which has not been tested.
