Table 2.

Compositions of twin screw granulation formulations with different binders and different methods of binder incorporation.

Formulation Ingredients*	F19	F20	F21	F22	F23	F24	F25	F26	F27	F28	F29	F30
Theophylline	33.3	33.3	33.3	33.3	33.3	33.3	33.3	33.3	33.3	33.3	33.3	33.3
Compritol® 888 ATO	20.0	20.0	20.0	-	-	-	-	-	-	10.0	10.0	-
Precirol® ATO 5	-	-	-	20.0	20.0	20.0	-	-	-	10.0	-	10.0
Geleol™	-	-	-	-	-	-	20.0	20.0	20.0	-	10.0	10.0
Avicel® DG	39.5	39.5	38.5	39.5	39.5	38.5	39.5	39.5	38.5	39.5	39.5	39.5
Klucel™ EF IG	-	3.0	4.0	-	3.0	4.0	-	3.0	4.0	3.0	3.0	3.0
HPC SSL (IG)	7.0	-	-	7.0	-	-	7.0	-	-	-	-	-
HPC SSL (EG)	-	4.0	4.0	-	4.0	4.0	-	4.0	4.0	4.0	4.0	4.0
Magnesium stearate	0.2	0.2	0.2	0.2	0.2	0.2	0.2	0.2	0.2	0.2	0.2	0.2

^*All the amounts are expressed as % w/w