Table 4.
Physical properties and assay values of wet granulation, direct compression and twin screw granulation formulations.
| Formulation code |
Flow properties | Physical properties of tablets | ||||
|---|---|---|---|---|---|---|
| Angle of repose |
Carr's Index (%) |
Hardness (KP) |
%Friability | Thickness(mm) | Assay (%) | |
| F1 | 28.3± 0.75 | 12.7± 1.75 | 16.3±1.22 | 0.16±0.01 | 5.98±0.05 | 98.8±1.14 |
| F2 | 27.5±0.93 | 14.3± 0.85 | 15.9±0.99 | 0.13±0.04 | 5.89±0.04 | 97.1±1.53 |
| F3 | 26.2± 1.11 | 13.9± 0.64 | 15.8±1.41 | 0.12±0.02 | 5.86±0.07 | 101±2.11 |
| F7 | 34.4± 0.39 | 21.6± 0.91 | 14.4±1.47 | 0.25±0.04 | 6.05±0.03 | 99.5±2.31 |
| F8 | 33.8± 1.12 | 20.3± 1.55 | 15.1±0.93 | 0.38±0.09 | 6.09±0.04 | 101±1.24 |
| F9 | 33.1± 2.12 | 19.8± 0.67 | 14.6±0.56 | 0.42±0.06 | 6.11±0.06 | 97.9±0.94 |
| F20 | 25.9± 1.63 | 12.3± 0.39 | 15.8±0.58 | 0.12±0.03 | 5.49±0.02 | 102±1.26 |
| F23 | 26.2± 1.85 | 13.1± 0.92 | 16.2±1.25 | 0.14±0.06 | 5.79±0.06 | 98.1±1.28 |
| F26 | 27.3± 1.47 | 11.9± 0.43 | 15.4±1.49 | 0.11±0.03 | 5.55±0.04 | 100.3±2.34 |