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. Author manuscript; available in PMC: 2018 Nov 15.
Published in final edited form as: Nat Chem. 2018 May 14;10(7):787–794. doi: 10.1038/s41557-018-0055-2

Figure 1. Schematic illustration of the concept of enrichment-triggered prodrug activation.

Figure 1

The two components would not click with each other during circulation at low concentrations. Upon enrichment in the targeted area, the significant increase in local concentrations leads to enhanced reaction rate, and thereby the drug is released in the targeted area.