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IC50 in Hela cell line (n = 3, p = 0.95)
| Compounds | IC50 (μM) |
|---|---|
| Dox-prodrug 6 | >100 |
| Alkyne 1 | >100 |
| Alkyne 3b | >50 |
| Dox | 1.0±0.2 |
| Dox-prodrug 6 + 50 μM 1 | 1.5±0.3 |
| Dox-prodrug 6 + 100 μM 1 | 1.3±0.2 |
| Dox-prodrug 6 + 50 μM 3b | 2.3±0.4 |
| Tetrazine 4+ 100 μM 1 | >100 |
