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A model of “leaky” RYR1 channel in pathological skeletal muscles. a RyR1 from normal skeletal muscle is not “leaky” and the sequestration of calcium ion occurred due to RYR1 activation which triggers muscle contraction b In pathological state, ROS and RNS mediated remodelling of RYR1 channel and impaired calcium homeostasis which may lead to decreased muscle force and moreover, it may lead to muscular atrophy
