Fig. 3.

Effect of MEK/ERK inhibition on EGF- and HGF-induced DNA synthesis. EGF (10 nM) or HGF (1 nM) was added to AsPC-1 (a) and Panc-1 (b) cells 30 min after adding PD98059 (20 μM) and DNA synthesis measured after 24 h of stimulation. The data represent the mean ± SEM of three independent experiments. * indicates p ≤ 0.05 and **indicates p ≤ 0.01 versus without PD98059