Table 4.
Relationships of tumor grade and invasion depth with tissue architecture n (%)
|
Tumor grade |
Invasion depth |
||||||
| Variable | Adenoma (n = 81) | Cancer1 (n = 49) | P value | SM invasion depth ≥ 1000 μm (n = 49) | SM invasion depth < 1000 μm (n = 31) | P value | |
| Lining epithelium degeneration/prolapse | Absent | 69 (85.2) | 20 (40.8) | 20 (40.8) | 1 (3.2) | ||
| Present | 12 (14.8) | 29 (59.2) | < 0.0001 | 29 (59.2) | 30 (96.8) | 0.001 | |
| Irregularity in glandular duct size/arrangement | Absent | 54 (66.7) | 10 (20.4) | 10 (20.4) | 1 (3.2) | ||
| Present | 27 (33.3) | 39 (79.6) | < 0.0001 | 39 (79.6) | 25 (80.6) | 0.113 | |
| Superficial differentiation | Well-diff. | 42 (85.7) | 42 (85.7) | 20 (64.5) | |||
| Moderately diff. | 7 (14.3) | 7 (14.3) | 10 (32.3) | ||||
| Poorly diff. | 0 (0.0) | 0 (0.0) | 1 (3.2) | 0.027 | |||
| Superficial desmoplastic reaction | Absent | 81 (100) | 47 (95.9) | 47 (95.9) | 17 (54.8) | ||
| Present | 0 (0.0) | 2 (4.1) | 0.273 | 2 (4.1) | 14 (45.2) | < 0.0001 | |
| Loss of muscularis mucosae | Absent | 0 (0.0) | 3 (6.1) | 3 (6.1) | 29 (93.5) | ||
| Present | 81 (100) | 46 (93.9) | 0.099 | 46 (93.9) | 2 (6.5) | < 0.0001 | |
| Granuloma formation | Absent | 80 (98.8) | 44 (89.8) | 44 (89.8) | 19 (61.3) | ||
| Present | 1 (1.2) | 5 (10.2) | 0.054 | 5 (10.2) | 2 (38.7) | 0.002 | |
1
Intramucosal cancer (confined to the mucosa); diff.: Differentiated; SM: Submucosa.