Table 2.
The CXC chemokines and their receptors
CXC ligand | Chemokine name | Receptor | ELR domain |
CXCL1 | Growth-regulated oncogene (Gro-α) | CXCR2 | ELR+ |
CXCL2 | Growth-regulated oncogene (Gro-β) | CXCR2 | ELR+ |
CXCL3 | Growth-regulated oncogene (Gro-γ) | CXCR2 | ELR+ |
CXCL4 | Platelet factor-4 (PF-4) | CXCR3 | ELR- |
CXCL5 | Epithelial cell-derived neutrophil-activating peptide-78 (ENA-78) | CXCR2 | ELR+ |
CXCL6 | Granulocyte chemotactic protein-2 (GCP-2) | CXCR1/2 | ELR+ |
CXCL7 | Neutrophil-activating peptide-2 (NAP-2) | CXCR2 | ELR+ |
CXCL8 | Interleukin-8 (IL-8) | CXCR1/2 | ELR+ |
CXCL9 | Monokine induced by interferon-γ (Mig) | CXCR3 | ELR- |
CXCL10 | Inducible protein-10 (IP-10) | CXCR3 | ELR- |
CXCL11 | Interferon-inducible T cell alpha chemoattractant (I-TAC) | CXCR3/7 | ELR- |
CXCL12 | Stromal cell-derived factor-1 (SDF-1) | CXCR4/7 | ELR- |
CXCL13 | B cell-attracting chemokine-1 (BCA-1) | CXCR5 | ELR- |
CXCL16 | Scavenger receptor that binds phosphatidylserine and oxidized lipoprotein (SR-PSOX) | CXCR6 | ELR- |
CXCL17 | VEGF-correlated chemokine-1 (VCC-1) | CXCR8 | ELR+ |
VEGF: Vascular endothelial growth factor.