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. 2018 Nov 14;9:4777. doi: 10.1038/s41467-018-07250-6

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© The Author(s) 2018

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 4 — In vivo T₂-weighted MR imaging. a Schematic representation of in vivo inflammation reaction after resecting partial glioma. Evaluation of the inflammation cytokines TNF-α (b) and IL-6 (c) levels in the brain of the U87-bearing mice after surgical treatment for 7 d. d In vivo T₂-weighted MR images of postsurgical glioma-bearing mice before and after intravenous injection of D-MMSNs and ND-MMSNs. The red circles point to the tumor site. e Relative signal intensities of postsurgical glioma as a function of time. f Histological analysis of brain tissues by Prussian blue staining. Scale bar: 50 μm. Mean values and error bars are defined as mean and s.d., respectively (n = 3)