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. 2018 Nov 14;9:4777. doi: 10.1038/s41467-018-07250-6

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© The Author(s) 2018

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 6 — In vivo therapeutic performance of ND-MMSNs. a Schematic illustration of in vivo therapeutic schedule of mice after U87-Luc glioma cells implantation, primary glioma resection, and treatment of ND-MMSNs delivery system. b In vivo bioluminescent images, c quantified signal intensity and d survival curves of U87 glioma-bearing mice from each group after various treatment indicated. Statistical significance is assessed by Student’s two-sided t test compared to the control group. **P < 0.01. e Quantified signal intensity and f survival curves of C6 glioma-bearing mice from each group after various treatment indicated. Statistical significance is assessed by Student’s two-sided t test compared to the control group. **P < 0.01. Mean values and error bars are defined as mean and s.d., respectively (n = 5)