Table 5.
Association between number of sexual partners and risk for aggressive prostate cancer vs. nonaggressive prostate cancer stratified by IFNL4 rs368234815 genotype
| IFNL4 ΔG/TT or ΔG/ΔG | IFNL4 TT/TT | |||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Control N (%) | Aggressive case N (%) | Nonaggressive case N (%) | Aggressive case Multivariablea OR (95% CI) | P valueb | Nonaggressive case Multivariablea OR (95% CI) | P valueb | Control N (%) | Aggressive case N (%) | Nonaggressive case N (%) | Aggressive case Multivariablea OR (95% CI) | P valueb | Nonaggressive case Multivariablea OR (95% CI) | P valueb | |
| When you were in your teens with how many different partners did you have intercourse? | ||||||||||||||
| 0–1 | 250 (41) | 41 (31) | 145 (36) | Ref. | Ref. | 152 (54) | 28 (47) | 68 (41) | Ref. | Ref. | ||||
| 2–9 | 312 (51) | 75 (56) | 211 (52) | 1.38 (0.86, 2.21) | 0.187 | 0.92 (0.68, 1.24) | 0.563 | 113 (40) | 27 (46) | 83 (50) | 1.19 (0.62, 2.28) | 0.607 | 1.20 (0.75, 1.90) | 0.447 |
| 10 or more | 47 (8) | 18 (13) | 47 (12) | 1.82 (0.90, 3.66) | 0.095 | 1.24 (0.76, 2.03) | 0.388 | 17 (6) | 4 (7) | 15 (9) | 0.72 (0.18, 2.92) | 0.648 | 1.43 (0.62, 3.29) | 0.400 |
| Ptrend 0.074 | Ptrend 0.716 | Ptrend 0.977 | Ptrend 0.324 | |||||||||||
| When you were in your 20s with how many different partners did you have intercourse? | ||||||||||||||
| 0–1 | 181 (29) | 26 (19) | 90 (21) | Ref. | Ref. | 96 (33) | 29 (43) | 49 (28) | Ref. | Ref. | ||||
| 2–9 | 334 (53) | 80 (57) | 230 (55) | 1.80 (1.07, 3.00) | 0.026 | 1.30 (0.93, 1.80) | 0.123 | 153 (52) | 27 (40) | 94 (53) | 0.49 (0.25, 0.96) | 0.036 | 0.99 (0.61, 1.61) | 0.978 |
| 10 or more | 115 (18) | 34 (24) | 102 (24) | 2.42 (1.30, 4.50) | 0.005 | 1.54 (1.04, 2.29) | 0.032 | 43 (15) | 12 (18) | 34 (19) | 0.75 (0.31, 1.81) | 0.524 | 1.26 (0.67, 2.35) | 0.474 |
| P trend 0.005 | P trend 0.032 | Ptrend 0.253 | Ptrend 0.527 | |||||||||||
| When you were in your 30s with how many different partners did you have intercourse? | ||||||||||||||
| 0–1 | 326 (52) | 53 (38) | 158 (37) | Ref. | Ref. | 172 (59) | 38 (55) | 93 (53) | Ref. | Ref. | ||||
| 2–9 | 229 (36) | 57 (41) | 203 (48) | 1.52 (0.95, 2.42) | 0.078 | 1.73 (1.27, 2.33) | 0.000 | 99 (34) | 24 (35) | 65 (37) | 1.18 (0.61, 2.27) | 0.630 | 0.96 (0.60, 1.54) | 0.873 |
| 10 or more | 74 (12) | 30 (21) | 61 (14) | 2.82 (1.56, 5.11) | 0.001 | 1.56 (1.02, 2.38) | 0.040 | 22 (8) | 7 (10) | 19 (11) | 1.12 (0.39, 3.21) | 0.827 | 1.37 (0.66, 2.86) | 0.395 |
| P trend 0.001 | P trend 0.005 | Ptrend 0.694 | Ptrend 0.575 | |||||||||||
| Throughout your life, what is the total number of partners with whom you have had sexual intercourse? | ||||||||||||||
| <5 | 199 (31) | 39 (27) | 92 (22) | Ref. | Ref. | 113 (39) | 29 (43) | 55 (31) | Ref. | Ref. | ||||
| 5–19 | 276 (43) | 44 (31) | 187 (44) | 1.08 (0.64, 1.81) | 0.783 | 1.38 (0.99, 1.94) | 0.058 | 110 (38) | 23 (34) | 69 (39) | 0.73 (0.37, 1.43) | 0.358 | 1.10 (0.67, 1.81) | 0.704 |
| 20 or more | 171 (26) | 60 (42) | 148 (35) | 2.32 (1.34, 4.02) | 0.003 | 1.67 (1.16, 2.43) | 0.006 | 70 (24) | 16 (24) | 54 (30) | 0.72 (0.31, 1.67) | 0.450 | 1.14 (0.64, 2.03) | 0.661 |
| P trend 0.001 | P trend 0.007 | Ptrend 0.403 | Ptrend 0.653 | |||||||||||
OR odds ratio, 95% CI 95% confidence interval
aUnconditional logistic regression adjusted for body mass index at study enrollment (BMI, kg m−2), age at study entry, education (high school or less, some college, college, professional school), family history of prostate cancer (first degree relatives, yes/no), smoking history (never, former, current), condom use (usually use, yes/no), aspirin use (regular user, yes/no), and race
Bolded data indicate significant associations in the multivariable logistic regression analysis
bBonferroni-corrected significance threshold for multiple comparisons (n = 16) is 0.003125