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. 2018 Nov 14;8:16809. doi: 10.1038/s41598-018-35011-4

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© The Author(s) 2018

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Close-up of vertebral segment within testing frame. (a) Full view of hexapod (6-axis load cell) testing robot. (b) Biomechanical assessment of degenerative L5/6 IVD motion segments injected with NTG-101 or PBS. The specimens’ properties (under flexion and right lateral flexion loading) of the NTG-101 injected discs are statistically significantly preserved compared to those injected with PBS (*p ≤ 0.05). (c) Model representing mechanism of action (MoA) of NTG-101 showing its anti-inflammatory, anti-catabolic and pro-anabolic effects in a degenerative IVD-NP. Treatment with NTG-101 suppresses inflammation induced expression of matrix degrading enzymes (MMP-3, MMP-13), cell death and pain associated molecules (Cox-2, PGE2).