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. 2018 Nov 14;8:16793. doi: 10.1038/s41598-018-34741-9

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© The Author(s) 2018

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Targets of Crc on bacterial metabolism and on the transport of carbon sources. The diagram represents schematically the main pathways of central carbon metabolism, some pathways of carbon sources catabolism, some of which elements are regulated by Crc, and transporters repressed by Crc. In black, key metabolites within central carbon metabolism, underlined the 12 precursors of biomolecules³⁰. In blue, genes encoding enzymes of central carbon metabolism which translation repress the protein Crc (PTV > 1), including Zwf (glucose-6-P 1-dehydrogenase), PgI (6-phosphogluconolactonase), Edd (6-phosphogluconate dehydratase), Eda (KDPG aldolase), Glk (glucokinase), Gcd (glucose dehydrogenase), GapA (GA3P dehydrogenase), AceE (pyruvate dehydrogenase), PycAB (pyruvate carboxylase), and FumC1 (fumarase). In grey, other pathways of central carbon metabolism that are not controlled by Crc. In yellow, secondary carbon sources which degradation is controlled by Crc, including a simplified pathway indicating its connection to central carbon metabolism and the number of enzymes which production is controlled by Crc. In red, the number of proteins related with the transport of such carbon source. This scheme has been done with the information of the databases Pseudomonas Genome database⁶¹, MetaCyc⁶² and TransportDB⁶³ and the information of the bibliography, specially refs^38,64. G6P, glucose-6-P; F6P, fructose-6-P; FBP, fructose-1,6-P₂; GA3P, glyceraldehyde-3-P; DHAP, dihydroxyacetone-P; BPG, 1,3-biphosphoglycerate; 2PG, 2-P-glycerate; 3PG, 3-P-glycerate; PEP, phosphoenolpyruvate; AcCoA, acetyl-coenzyme A; 6PG, 6-P-gluconate; KDPG, 2-keto-3-deoxy-6-P-gluconate; αKG, α-ketoglutarate; SucCoA, succinyl-coenzyme A; OAA, oxaloacetate; E4P, erythrose-4-P; R5P, ribulose-5-P; G3P, glycerol-3-P; D-Ala, D-alanine; β-Ala, β-alanine; γ-AB, γ-aminobutyrate.