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. 2018 Nov 14;8:16793. doi: 10.1038/s41598-018-34741-9

Table 1.

Transcriptomic, proteomic and post-transcriptional changes for selected genes.

Category Name ID Description TC PC PTV
Catabolism bauC PA0130 3-Oxopropanoate dehydrogenase −1,02 1,03 3,94
Catabolism bauA PA0132 Beta-alanine: pyruvate transaminase −1,36 1,41 5,37
Other siaD PA0169 SiaD 1,27 1,05 1,72
Other siaC PA0170 Hypothetical protein 1,39 0,96 1,33
Other siaB PA0171 Hypothetical protein 1,5 1,44 2,6
Catabolism gabT PA0266 Delta-aminovalerate aminotransferase −1,69 −0,21 1,1
Catabolism spuA PA0297 Probable glutamine amidotransferase −0,39 0,6 2,11
Catabolism spuB PA0298 Glutamylpolyamine synthetase −0,51 0,53 2,01
Catabolism spuC PA0299 Polyamine:pyruvate transaminase −0,57 0,31 1,46
Transport spuD PA0300 Polyamine transport protein −0,02 0,49 1,4
Catabolism gcdG PA0446 Conserved hypothetical protein 1,55 1,43 2,52
Catabolism gcdH PA0447 Glutaryl-CoA dehydrogenase 2,64 1,09 0,48
Iron fiuA PA0470 Ferrichrome receptor FiuA −0,24 1,05 3,22
Transport agtA PA0603 AgtA −6,4 −0,12 6,07
Transport agtB PA0604 AgtB −5,35 0,05 5,5
Transport agtC PA0605 AgtC −5,14 0,08 5,36
Iron hemO PA0672 Heme oxygenase 0,51 2,55 6,75
Catabolism PA0744 Probable enoyl-CoA hydratase/isomerase 1,86 1,28 1,78
Transport tctC PA0754 Hypothetical protein 0,06 2,8 7,9
Transport opdH PA0755 Cis-aconitate porin OpdH −0,5 2,54 7,72
Catabolism putA PA0782 Proline dehydrogenase PutA −3,29 1,79 8,38
Transport putP PA0783 Sodium/proline symporter PutP −0,79 1,58 5,3
Transport PA0789 Probable amino acid permease 0,38 0,86 2,08
Iron pirA PA0931 Ferric enterobactin receptor PirA 0,29 0,97 2,48
Transport tolQ PA0969 TolQ protein 0,41 1,03 2,52
Transport tolR PA0970 TolR protein 0,33 0,62 1,43
Transport gntP PA1051 Probable transporter −2,46 0,33 3,4
Transport braG PA1070 Branched-chain amino acid transport protein BraG 0,94 0,79 1,32
Transport braF PA1071 Branched-chain amino acid transport protein BraF 1,06 1,07 2
Transport braC PA1074 Branched-chain amino acid transport protein BraC 0,96 1,47 3,21
Transport fadL PA1288 Probable outer membrane protein precursor −0,13 0,57 1,74
Catabolism gbuA PA1421 Guanidinobutyrase −3,52 −0,37 2,45
Transport kdpB PA1634 Potassium-transporting ATPase 3,46 1,19 −0,06
Catabolism pauD 2 PA1742 Glutamine amidotransferase class I −0,68 0,55 2,23
Transport oppD PA1808 NppC 0,66 0,65 1,18
Catabolism ldcA PA1818 Lysine decarboxylase 1,28 1,49 2,96
Transport modA PA1863 Molybdate-binding periplasmic protein precursor ModA 0,21 0,76 1,94
Catabolism dhcA PA1999 Dehydrocarnitine CoA transferase 4,29 2,37 2,46
Catabolism dhcB PA2000 Dehydrocarnitine CoA transferase 4,07 1,99 1,61
Catabolism atoB PA2001 Acetyl-CoA acetyltransferase 3,42 2,44 3,51
Transport atoE PA2002 Conserved hypothetical protein 3,7 2,84 4,37
Catabolism maiA PA2007 Maleylacetoacetate isomerase 3,66 1,86 1,62
Catabolism fahA PA2008 Fumarylacetoacetase 3,24 2,58 4,09
Catabolism hmgA PA2009 Homogentisate 1-2dioxygenase 3,36 1,68 1,43
Catabolism liuC PA2013 Putative 3-methylglutaconyl-CoA hydratase 2,27 1,76 2,74
Catabolism liuB PA2014 Methylcrotonyl-CoA carboxylase 2,37 1,32 1,39
Catabolism liuA PA2015 Putative isovaleryl-CoA dehydrogenase 2,16 2,06 3,69
Catabolism pauA4 PA2040 Glutamylpolyamine synthetase −1 0,16 1,47
Catabolism kynU PA2080 Kynureninase KynU 0,48 0,54 1,05
Transport opdO PA2113 Pyroglutamate porin OpdO 7,97 3,03 0,65
Transport PA2204 Probable binding protein component of ABC transporter 2,01 1,33 1,77
Other pslA PA2231 PslA 1,56 1,16 1,74
Other pslD PA2234 PslD 2,03 1,44 2,06
Other pslE PA2235 PslE 1,93 1,2 1,49
Other pslF PA2236 PslF 2,03 1,08 1,05
Other pslH PA2238 PslH 2,19 1,23 1,3
Catabolism bkdA1 PA2247 2-oxoisovalerate dehydrogenase (alpha subunit) 3,61 1,96 5,58
Catabolism bkdA2 PA2248 2-oxoisovalerate dehydrogenase (beta subunit) 3,98 2,79 7,95
Catabolism bkdB PA2249 Branched-chain alpha-keto acid dehydrogenase (lipoamide component) 3,99 2,17 6,18
Catabolism lpdV PA2250 Lipoamide dehydrogenase-Val 4,12 2,35 6,69
Transport PA2252 Probable AGCS sodium/alanine/glycine symporter −3,32 0,89 5,85
Catabolism ansA PA2253 L-asparaginase I −2,19 0,31 3,07
CCM/catabolism gcd PA2290 Glucose dehydrogenase 0,8 0,7 1,2
Transport oprB2 PA2291 Probable glucose-sensitive porin 1,37 2,56 5,91
Iron pvdA PA2386 L-ornithine N5-oxygenase 1,39 3,11 7,46
Iron pvdF PA2396 Pyoverdine synthetase F 0,58 2,01 5,14
Iron fpvA PA2398 Ferripyoverdine receptor 1,2 1,11 1,96
Iron pvdD PA2399 Pyoverdine synthetase D 1,14 0,93 1,52
Catabolism gcvT2 PA2442 Glycine cleavage system protein T2 2,63 1,7 2,2
Catabolism glyA2 PA2444 Serine hydroxymethyltransferase 2,37 1,15 0,9
Catabolism gcvP2 PA2445 Glycine cleavage system protein P2 2,51 1,98 3,13
Catabolism gcvH2 PA2446 Glycine cleavage system protein H2 2,68 2,37 4,08
Catabolism PA2552 Probable acyl-CoA dehydrogenase 3,27 1,72 1,61
Catabolism PA2553 Probable acyl-CoA thiolase 4,09 2,36 2,63
Transport oprQ PA2760 OprQ 0,33 0,89 2,21
Catabolism pauB3 PA2776 FAD-dependent oxidoreductase −1,55 0,2 2,13
CCM/catabolism eda PA3181 2-keto-3-deoxy-6-phosphogluconate aldolase −0,29 1,6 4,84
CCM/catabolism pgl PA3182 6-phosphogluconolactonase −0,64 1,71 5,53
CCM/catabolism zwf PA3183 Glucose-6-phosphate 1-dehydrogenase −1,18 1,63 5,83
Transport oprB PA3186 Glucose/carbohydrate outer membrane porin OprB precursor 2,35 2,76 5,5
Transport gltK PA3187 Probable ATP-binding component of ABC transporter −0,22 2,29 6,75
Transport gltG PA3188 Probable permease of ABC sugar transporter −0,46 3,56 10,6
Transport gltB PA3190 Probable binding protein component of ABC sugar transporter 0,2 2,92 8,1
CCM/catabolism glk PA3193 Glucokinase 0,02 1,11 3,15
CCM/catabolism edd PA3194 Phosphogluconate dehydratase −1,07 1,11 4,22
CCM gapA PA3195 Glyceraldehyde 3-phosphate dehydrogenase −0,1 2,08 6,02
Transport PA3271 Probable two-component sensor −2,75 −0,32 1,85
Catabolism pauA5 PA3356 Glutamylpolyamine synthetase −0,85 0,13 1,21
Catabolism amiE PA3366 Aliphatic amidase 1,95 1,72 2,95
Catabolism PA3579 Probable carbohydrate kinase −1,76 −0,23 1,1
Catabolism glpK PA3582 Glycerol kinase −1,93 1,44 6,02
Catabolism glpD PA3584 Glycerol-3-phosphate dehydrogenase −2,87 0,16 3,31
Transport PA3690 Probable metal-transporting P-type ATPase −0,46 1,02 3,36
Transport PA3760 N-Acetyl-D-Glucosamine phosphotransferase system transporter −0,5 0,44 1,76
Transport PA3779 Hypothetical protein 0 0,89 2,54
Transport PA3838 Probable ATP-binding component of ABC transporter −0,44 0,49 1,84
Iron fecA PA3901 Fe(III) dicitrate transport protein FecA −0,44 1,36 4,31
Catabolism PA3925 Probable acyl-CoA thiolase 0,33 0,85 2,1
Catabolism PA4198 Probable AMP-binding enzyme −0,83 0,88 3,32
CCM fumC1 PA4470 Fumarate hydratase −0,24 1,3 3,71
Transport PA4496 Probable binding protein component of ABC transporter 1,45 1,72 3,44
Transport PA4500 Probable binding protein component of ABC transporter 3,37 2,33 3,27
Transport opdP PA4501 Glycine-glutamate dipeptide porin OpdP 4,52 2,52 2,66
Transport PA4502 Probable binding protein component of ABC transporter 4,52 2,58 2,83
Transport PA4503 Dipeptide ABC transporter permease DppB 4,43 2,3 2,12
Transport PA4504 Dipeptide ABC transporter permease DppC 4,85 2,37 1,88
Transport PA4505 Dipeptide ABC transporter ATP-binding protein DppD 4,61 2,35 2,08
Transport PA4506 Dipeptide ABC transporter ATP-binding protein DppF 4,55 2,16 1,59
Iron piuB PA4513 Probable oxidoreductase 0,66 0,84 1,73
Iron piuA PA4514 Probable outer membrane receptor for iron transport 0,87 1,99 4,8
Iron piuC PA4515 Conserved hypothetical protein 0,73 0,93 1,91
Iron chtA PA4675 ChtA −0,11 1,03 3,03
Iron/transport phuT PA4708 Heme-transport protein 0,22 1,91 5,22
Iron/transport phuS PA4709 PhuS 0,29 1,98 5,33
Iron/transport phuR PA4710 Heme/Hemoglobin uptake outer membrane receptor PhuR precursor −0,46 2,31 7,03
CCM aceE PA5015 Pyruvate dehydrogenase 0,5 0,56 1,09
Transport PA5152 Probable ATP-binding component of ABC transporter −0,09 1,2 3,51
Transport PA5153 Amino acid (lysine/arginine/ornithine/histidine/octopine) ABC transporter periplasmic binding protein 0,8 1,32 2,95
Transport dctP PA5167 DctP 2,07 2,44 4,87
Transport dctQ PA5168 DctQ 1,98 2 3,72
Transport PA5217 Probable binding protein component of ABC iron transporter −0,01 0,83 2,37
Catabolism dadX PA5302 Catabolic alanine racemase 1,34 1,41 2,67
Catabolism dadA PA5304 D-amino acid dehydrogenase 0,99 1,32 2,76
Catabolism pauB4 PA5309 FAD-dependent oxidoreductase −0,73 0,14 1,14
Catabolism pauC PA5312 Aldehyde dehydrogenase −1,49 0,2 2,07
Transport pstB PA5366 ATP-binding component of ABC phosphate transporter −0,44 0,24 1,13
Transport pstA PA5367 Membrane protein component of ABC phosphate transporter 0 0,5 1,42
Transport pstS PA5369 Phosphate ABC transporter −0,22 0,28 1,02
Catabolism aspA PA5429 Aspartate ammonia-lyase −0,05 0,6 1,76
CCM pycB PA5435 Probable transcarboxylase subunit 1,69 1,05 1,29
CCM pycA PA5436 Probable biotin carboxylase subunit of a transcarboxylase 1,09 0,88 1,4
Transport PA5504 D-methionine ABC transporter membrane protein −0,19 0,29 1,01
Catabolism pauA7 PA5508 Glutamylpolyamine synthetase homologue −4,03 0,8 6,32
Transport PA5510 Probable transporter −2,56 0,44 3,82
Catabolism PA5523 Probable aminotransferase −0,55 0,33 1,49
Iron tonB1 PA5531 TonB1 0,28 1,18 3,08
Transport PA5545 Conserved hypothetical protein −0,19 0,86 2,64

ID: Gene code as annotated in http://pseudomonas.com, TC: transcript change; PC: protein change; PTV: post-transcriptional variation parameter. CCM: Central carbon metabolism. Underlined, genes that have been described as potential Crc targets in10. Highlighted in bold contiguous genes, transcribed in the same strand, which can form operons.