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. 2018 Nov 14;8:16814. doi: 10.1038/s41598-018-35254-1

Figure 4.

Figure 4

Effect of GAL (4 mg/kg; i.p) and/or MLA (5.6 mg/kg; i.p) on renal histopathological changes in ZYM-induced AKI. Sections of ZYM treated animals show [c] cytoplasmic vacuolization (V) of epithelial lining renal tubules, congestion (C), and hypercellularity of glomerular tuft (large arrow), besides [d] perivascular inflammatory cells (IC) infiltration, compared to [a and b] CONT mice showing the normal histological structure of renal tubules (T) and glomeruli (G). Sections of GAL show [e] no histopathological changes in both renal tubules (T) and glomeruli (G) or [f] slight cytoplasmic vacuolization (V) and slight congestion (C) of glomerular tuft. Sections of MLA + GAL show [g] cytoplasmic vacuolization (V) of epithelial lining of some renal tubules, with congestion (C) of glomerular tuft and renal blood vessels, in addition to [h] necrosis (N) of epithelial lining renal tubules (H&E X 400).